Accumulation of TRPV2 at the cell surface was 4-fold greater in the growth cone compared with the soma. Overexpression of TRPV2 enhanced axonal outgrowth in a mechanical stimulus-dependent manner. In the present study, we examined this mechanism by using PC12 cells as a neuronal model. We have previously reported that transient receptor potential vanilloid 2 (TRPV2) can be activated by mechanical stimulation, which enhances axonal outgrowth in developing neurons however, the molecular mechanisms that govern the contribution of TRPV2 activation to axonal outgrowth remain unclear.
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